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趨化因子是當(dāng)今細(xì)胞因子研究領(lǐng)域的熱點(diǎn)之一,它參與多種免疫及炎癥反應(yīng),在感染、腫瘤的生長(zhǎng)與轉(zhuǎn)移、組織修復(fù)及創(chuàng)傷愈合等病理生理過(guò)程中發(fā)揮重要作用.
C-C型趨化因子受體1（CCR1）主要在嗜酸粒細(xì)胞，Th2淋巴細(xì)胞，肥大細(xì)胞，支氣管上皮細(xì)胞上表達(dá).CCR1在腫瘤的生長(zhǎng)與轉(zhuǎn)移方面起到一定的作用。
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha （MIP1 alpha）, regulated on activation normal T expressed and secreted protein （RANTES）, monocyte chemoattractant protein 3 （MCP3）, and myeloid progenitor inhibitory factor 1 （MPIF1）. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. Also named as C C chemokine receptor type 1; C C CKR 1; CC CKR 1; CCR 1; CD 191; CD191; CD191 antigen; Chemokine （C-C motif） receptor 1; Chemokine C C motif receptor 1; CKR 1; CKR1; CMKBR 1; CMKBR1; CMKR 1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1 alpha receptor; MIP 1alpha R; MIP1aR; RANTES R; RANTES receptor; SCYAR1.
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